Supplementary Materials

Supplementary Material for:

Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2-deficient mice

Aslihan Selimbeyoglu, Christina K. Kim, Masatoshi Inoue, Soo Yeun Lee, Alice S. O. Hong, Isaac Kauvar, Charu Ramakrishnan, Lief E. Fenno, Thomas J. Davidson, Matthew Wright, Karl Deisseroth*

*Corresponding author. Email: deissero{at}stanford.edu

Published 2 August 2017, Sci. Transl. Med. 9, eaah6733 (2017)
DOI: 10.1126/scitranslmed.aah6733

This PDF file includes:

  • Fig. S1. Bilateral expression of SwiChR++ in mPFC.
  • Fig. S2. CNTNAP2 KO and WT mice interact with objects similarly both in the presence and absence of SSFO recruitment.
  • Fig. S3. Both SSFO and SwiChR++ recruitments rescue CNTNAP2 KO hyperactivity in the open-field test.
  • Fig. S4. Modulation of outgoing corticostriatal activity traffic by SSFO recruitment in mPFC PV neurons.
  • Fig. S5. Temporal details of interactions with familiar mouse and novel object.
  • Fig. S6. Modulation of PV neuron activity with locomotion.
  • Table S1. Raw data of Fig. 1E.
  • Table S2. Raw data of Fig. 1H.
  • Table S3. Raw data of Fig. 1I.
  • Table S4. Raw data of Fig. 1K.
  • Table S5. Raw data of Fig. 2B.
  • Table S6. Raw data of Fig. 2C.
  • Table S7. Raw data of Fig. 2D.
  • Table S8. Raw data of Fig. 2E.
  • Table S9. Raw data of Fig. 2G.
  • Table S10. Raw data of Fig. 2H.
  • Table S11. Raw data of Fig. 2I.
  • Table S12. Raw data of Fig. 2J.
  • Table S13. Raw data of Fig. 3G.
  • Table S14. Raw data of Fig. 3H.
  • Legends for movies S1 and S2

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). CNTNAP2 KO mPFC PV neuron activity during social behavior.
  • Movie S2 (.mov format). WT mPFC PV neuron activity during social behavior.