Supplementary Materials

Supplementary Material for:

In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs

Maxim Bez, Dmitriy Sheyn, Wafa Tawackoli, Pablo Avalos, Galina Shapiro, Joseph C. Giaconi, Xiaoyu Da, Shiran Ben David, Jayne Gavrity, Hani A. Awad, Hyun W. Bae, Eric J. Ley, Thomas J. Kremen, Zulma Gazit, Katherine W. Ferrara, Gadi Pelled, Dan Gazit*

*Corresponding author. Email: dan.gazit{at}

Published 17 May 2017, Sci. Transl. Med. 9, eaal3128 (2017)
DOI: 10.1126/scitranslmed.aal3128

This PDF file includes:

  • Fig. S1. Critical-sized bone fracture model in Yucatán mini-pigs’ tibia.
  • Fig. S2. Endogenous mesenchymal progenitor cell recruitment to mini-pig tibial fracture site.
  • Fig. S3. Ultrasound treatment setup.
  • Fig. S4. Biodistribution of BMP-6 expression after ultrasound-mediated gene delivery.
  • Fig. S5. Comparison of bone formation between male and female mini-pigs.
  • Legend for table S1
  • Legend for data file S1

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Primary data.
  • Data file S1 (.m format). MATLAB code of biomechanical analysis.