Supplementary Materials

Supplementary Material for:

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure

Qiming Duan, Sarah McMahon, Priti Anand, Hirsh Shah, Sean Thomas, Hazel T. Salunga, Yu Huang, Rongli Zhang, Aarathi Sahadevan, Madeleine E. Lemieux, Jonathan D. Brown, Deepak Srivastava, James E. Bradner, Timothy A. McKinsey, Saptarsi M. Haldar*

*Corresponding author. Email: saptarsi.haldar{at}gladstone.ucsf.edu

Published 17 May 2017, Sci. Transl. Med. 9, eaah5084 (2017)
DOI: 10.1126/scitranslmed.aah5084

This PDF file includes:

  • Fig. S1. Echocardiographic data from sham- and TAC-treated mice at day 53.
  • Fig. S2. Transcriptomic effects of chronic JQ1 administration in baseline (sham-operated) hearts.
  • Fig. S3. GSEA and fingerprinting analysis of differentially expressed genes in mouse LV.
  • Fig. S4. Additional qRT-PCR of exercise-regulated genes in mouse left ventricle.
  • Fig. S5. qRT-PCR and GSEA in human iPSC-CMs.
  • Legends for tables S1 to S6

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Normalized RNA-seq expression data for sham-vehicle and sham-JQ1 groups.
  • Table S2 (Microsoft Excel format). Normalized RNA-seq expression data for sham-vehicle, TAC-vehicle, and TAC-JQ1 groups.
  • Table S3 (Microsoft Excel format). Normalized RNA-seq expression data for sham-vehicle, MI-vehicle, and MI-JQ1 groups.
  • Table S4 (Microsoft Excel format). List of 193 genes in the Venn overlap in Fig. 4A.
  • Table S5 (Microsoft Excel format). Normalized RNA-seq expression data from human iPSC-CMs for unstimulated, ET-1, and ET-1 + JQ1 groups.
  • Table S6 (Microsoft Excel format). List of qRT-PCR primers and TaqMan probes.

[Download Tables S1 to S6]