Supplementary Materials

Supplementary Material for:

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease

Min Wei, Sebastian Brandhorst, Mahshid Shelehchi, Hamed Mirzaei, Chia Wei Cheng, Julia Budniak, Susan Groshen, Wendy J. Mack, Esra Guen, Stefano Di Biase, Pinchas Cohen, Todd E. Morgan, Tanya Dorff, Kurt Hong, Andreas Michalsen, Alessandro Laviano, Valter D. Longo*

*Corresponding author. Email: vlongo{at}

Published 15 February 2017, Sci. Transl. Med. 9, eaai8700 (2017)
DOI: 10.1126/scitranslmed.aai8700

This PDF file includes:

  • Materials and Methods
  • Table S1. Complete metabolic panel.
  • Table S2. Arm-specific markers of adherence and changes in risk factors, including arm 1 after crossover to FMD, and summary of FMD arms 1 and 2.
  • Table S3. Changes in risk factors and metabolic markers of adherence after the first FMD.
  • Table S4. Changes in risk factors and metabolic markers of adherence 3 months after intervention.
  • Fig. S1. Subject self-reported adverse effects based on CTCAE.
  • Fig. S2. Comparison of participants who completed the trial versus dropouts.
  • Fig. S3. Baseline to 3 months before/after comparison of individual subjects in the control cohort and all subjects who completed the FMD.
  • Fig. S4. Nutritional information of the FMD.
  • CONSORT checklist
  • Trial protocols

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