Supplementary Materials

Supplementary Material for:

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension

Sabine Kossmann, Jeremy Lagrange, Sven Jäckel, Kerstin Jurk, Moritz Ehlken, Tanja Schönfelder, Yvonne Weihert, Maike Knorr, Moritz Brandt, Ning Xia, Huige Li, Andreas Daiber, Matthias Oelze, Christoph Reinhardt, Karl Lackner, Andras Gruber, Brett Monia, Susanne H. Karbach, Ulrich Walter, Zaverio M. Ruggeri, Thomas Renné, Wolfram Ruf, Thomas Münzel, Philip Wenzel*

*Corresponding author. Email: wenzelp{at}

Published 1 February 2017, Sci. Transl. Med. 9, eaah4923 (2017)
DOI: 10.1126/scitranslmed.aah4923

This PDF file includes:

  • Fig. S1. Therapeutic targeting of FXI protects from vascular inflammation.
  • Fig. S2. Protein expression of gp91phox and HO-1.
  • Legends for videos S1 to S8

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Other Supplementary Material for this manuscript includes the following:

  • Video S1 (.mp4 format). C57BL/6.
  • Video S2 (.mp4 format). C57BL/6 + ATII.
  • Video S3 (.mp4 format). C57BL/6 + ATII + control IgG.
  • Video S4 (.mp4 format). C57BL/6 + ATII + anti–VCAM-1 antibody.
  • Video S5 (.mp4 format). C57BL/6 + Scr ASO.
  • Video S6 (.mp4 format). C57BL/6 + ATII + Scr ASO.
  • Video S7 (.mp4 format). C57BL/6 + FXI ASO.
  • Video S8 (.mp4 format). C57BL/6 + ATII + FXI ASO.