Supplementary Materials

Supplementary Material for:

Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies

Constantinos Petrovas,* Sara Ferrando-Martinez, Michael Y. Gerner, Joseph P. Casazza, Amarendra Pegu, Claire Deleage, Arik Cooper, Jason Hataye, Sarah Andrews, David Ambrozak, Perla M. Del Río Estrada, Eli Boritz, Robert Paris, Eirini Moysi, Kristin L. Boswell, Ezequiel Ruiz-Mateos, Ilias Vagios, Manuel Leal, Yuria Ablanedo-Terrazas, Amaranta Rivero, Luz Alicia Gonzalez-Hernandez, Adrian B. McDermott, Susan Moir, Gustavo Reyes-Terán, Fernando Docobo, Giuseppe Pantaleo, Daniel C. Douek, Michael R. Betts, Jacob D. Estes, Ronald N. Germain, John R. Mascola, Richard A. Koup

*Corresponding author. Email: petrovasc{at}

Published 18 January 2017, Sci. Transl. Med. 9, eaag2285 (2017)
DOI: 10.1126/scitranslmed.aag2285

This PDF file includes:

  • Materials and Methods
  • Fig. S1. T cell dynamics in HIV-infected LNs.
  • Fig. S2. Representative example of the histo-cytometry analysis.
  • Fig. S3. Dynamics of fCD8 with respect to HIV antigen distribution and collagen deposition in the LN areas.
  • Fig. S4. Gene signatures of sorted tissue CD8 T cell populations.
  • Fig. S5. Expression of exhaustion markers in fCD8 T cells.
  • Fig. S6. Expression of PD-1 in fCD8 T cells.
  • Fig. S7. Functionality of fCD8 T cells.
  • Fig. S8. Localization of GrzB+ CD8 T cells in the GC.
  • Fig. S9. fCD8 T cells can mediate in vitro bispecific antibody killing.
  • Table S1. Demographic (age and gender) and clinical (CD4 counts, pVL, and treatment) data of the donors as well as the type of assay used for their tissue analysis are shown.
  • References (5259)

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