Supplementary Materials

Supplementary Material for:

Optimized temporal pattern of brain stimulation designed by computational evolution

David T. Brocker, Brandon D. Swan, Rosa Q. So, Dennis A. Turner, Robert E. Gross, Warren M. Grill*

*Corresponding author. Email: warren.grill{at}

Published 4 January 2017, Sci. Transl. Med. 9, eaah3532 (2017)
DOI: 10.1126/scitranslmed.aah3532

This PDF file includes:

  • Fig. S1. Effect of stimulation pattern on total distance traveled during the methamphetamine-induced circling task.
  • Fig. S2. Effects of stimulation patterns on finger-tapping rates in persons with PD and STN DBS.
  • Fig. S3. Estimated battery longevity by subject with GA DBS compared to their clinical parameters.
  • Fig. S4. Examples of postmortem histology.
  • Fig. S5. Finger-tapping log CV duration for all three finger-tapping trials in each 5-min epoch.
  • Fig. S6. Example data from a subject who did not exhibit a β peak in the spectrum of field potentials recorded in STN.
  • Fig. S7. Histograms of tap duration for each subject in the finger-tapping task.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Individual subject-level data.