Supplementary Materials

Supplementary Material for:

Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury

Marc Suárez-Calvet, Miguel Ángel Araque Caballero, Gernot Kleinberger, Randall J. Bateman, Anne M. Fagan, John C. Morris, Johannes Levin, Adrian Danek, Michael Ewers,* Christian Haass,* for the Dominantly Inherited Alzheimer Network

*Corresponding author. Email: christian.haass{at}mail03.med.uni-muenchen.de (C.H.); michael.ewers{at}med.uni-muenchen.de (M.E.)

Published 14 December 2016, Sci. Transl. Med. 8, 369ra178 (2016)
DOI: 10.1126/scitranslmed.aag1767

This PDF file includes:

  • Materials and Methods
  • Table S1. CSF sTREM2 as a function of mutation status, age, gender, and APOE ε4 status.
  • Table S2. CSF sTREM2 as a function of EYO and mutation status.
  • Table S3. CSF sTREM2 estimates in MCs and NCs as a function of EYO and adjusted for age.
  • Table S4. CSF sTREM2 estimates in MCs and NCs as a function of EYO and adjusted for APOE ε4 status.
  • Table S5. CSF sTREM2 estimates in MCs and NCs as a function of EYO and adjusted for education.
  • Table S6. CSF sTREM2 absolute value estimates (ng/ml) in MCs and NCs as a function of EYO.
  • Table S7. Modeling the relationships between CSF sTREM2 and other markers as a function of EYO.
  • Table S8. Modeling the relationships between EYO and each marker for linear, quadratic, and cubic effects of EYO.
  • Fig. S1. CSF sTREM2 absolute level estimates (ng/ml) at specific EYOs.
  • Fig. S2. Marker trajectories modeled with different order EYO terms.

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