Supplementary Materials

Supplementary Material for:

Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease

Anamitra Ghosh, Trevor Tyson, Sonia George, Erin N. Hildebrandt, Jennifer A. Steiner, Zachary Madaj, Emily Schulz, Emily Machiela, William G. McDonald, Martha L. Escobar Galvis, Jeffrey H. Kordower, Jeremy M. Van Raamsdonk, Jerry R. Colca, Patrik Brundin*

*Corresponding author. Email: patrik.brundin{at}vai.org

Published 7 December 2016, Sci. Transl. Med. 8, 368ra174 (2016)
DOI: 10.1126/scitranslmed.aag2210

This PDF file includes:

  • Materials and Methods
  • Fig. S1. MSDC-0160 protects dopaminergic neurons against MPP+-induced toxicity in LUHMES cells and C. elegans.
  • Fig. S2. Modulation of MPC improves mitochondrial function.
  • Fig. S3. Time-course treatment of MSDC-0160 in LUHMES cells.
  • Fig. S4. MSDC-0160 improves behavioral parameters in the MPTP mouse model.
  • Fig. S5. MSDC-0160 improves behavioral activities in the En1+/− mice.
  • Fig. S6. MSDC-0160 prevents dopaminergic neurodegeneration in the En1+/− mice.
  • Fig. S7. MSDC-0160 down-regulates mTOR signaling pathway and restores autophagy in the En1+/− mice.
  • Fig. S8. MSDC-0160 attenuates inflammation in BV2 cells and in vivo animal models.
  • Fig. S9. MSDC-0160 improves mitochondrial function and blocks mTOR activation in BV2 cells.
  • Fig. S10. Schematic diagram of proposed mechanism of action of MSDC-0160 in glial cells and dopaminergic neurons.
  • Table S1. LMM results.
  • Reference (98)

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