Supplementary Materials

Supplementary Material for:

A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat

Ahyeon Koh, Daeshik Kang, Yeguang Xue, Seungmin Lee, Rafal M. Pielak, Jeonghyun Kim, Taehwan Hwang, Seunghwan Min, Anthony Banks, Philippe Bastien, Megan C. Manco, Liang Wang, Kaitlyn R. Ammann, Kyung-In Jang, Phillip Won, Seungyong Han, Roozbeh Ghaffari, Ungyu Paik, Marvin J. Slepian, Guive Balooch, Yonggang Huang, John A. Rogers*

*Corresponding author. Email: jrogers{at}illinois.edu

Published 23 November 2016, Sci. Transl. Med. 8, 366ra165 (2016)
DOI: 10.1126/scitranslmed.aaf2593

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Fabrication procedures of the epidermal microfluidic device.
  • Fig. S2. Determination of adhesion forces and conformal adhesion between the device and skin.
  • Fig. S3. Observations of sweat at the interface between an adhesive layer and the skin.
  • Fig. S4. Normal (A) and shear (B) stress distribution at the device/skin interface under 30% stretch.
  • Fig. S5. Mechanical modeling results for NFC electronics.
  • Fig. S6. Color balancing performed by internal calibration makers (black crosses and white circle) under various light conditions (A to F) and changes in numeric RGB representation obtained by respective images (G) before and (H) after white balance.
  • Fig. S7. Image processing for position calibration.
  • Fig. S8. Cross-sectional sketch of the microfluidic channel and outlet channel geometry used, and analytical analysis of backpressure and inner pressure.
  • Fig. S9. Strategies and optimization of the orbicular channel design.
  • Fig. S10. Schematic illustration of the artificial sweat pore system.
  • Fig. S11. Hydrodynamic test to verify the influence of the hydrogel matrix on channel volume.
  • Fig. S12. Assessment of the angular position of the liquid front in partially filled serpentine channels in devices with different hydrogel concentrations and segmented hydrogel patterns.
  • Fig. S13. Quantitative colorimetric analysis of glucose at low concentrations.
  • Fig. S14. Colorimetric analysis of device response as a function of time after introduction of artificial sweat.
  • Fig. S15. Various device configurations.
  • Fig. S16. Multivariate statistical analysis for correlations in marker concentrations between patch (p) and laboratory (l) analysis.
  • References (57, 58)

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). NFC between an epidermal microfluidic device and a smartphone to launch software for image capture and analysis.
  • Movie S2 (.avi format). NFC between an epidermal microfluidic device and a smartphone to launch software for temperature sensing.
  • Movie S3 (.avi format). Hydrodynamic flow in the serpentine channel of epidermal microfluidics on the artificial pore system.
  • Movie S4 (.avi format). Hydrodynamic flow in the detection reservoir of epidermal microfluidics on the artificial pore system.

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