Supplementary Materials

Supplementary Material for:

Reloadable multidrug capturing delivery system for targeted ischemic disease treatment

Jasmine P. J. Wu, Bill Cheng, Steve R. Roffler*, David J. Lundy, Christopher Y. T. Yen, Peilin Chen, James J. Lai, Suzie H. Pun, Patrick S. Stayton, Patrick C. H. Hsieh*

*Corresponding author. Email: phsieh{at}ibms.sinica.edu.tw (P.C.H.H.); sroff{at}ibms.sinica.edu.tw (S.R.R.)

Published 16 November 2016, Sci. Transl. Med. 8, 365ra160 (2016)
DOI: 10.1126/scitranslmed.aah6228

This PDF file includes:

  • Fig. S1. Binding of anti-PEG antibody, AGP4, to PEGylated compounds.
  • Fig. S2. Characterization of fluorescently labeled AGP4 and PEG-Qd800.
  • Fig. S3. Schematic diagrams showing the setup for the intravital multiphoton microscopy experiment.
  • Fig. S4. Toxicity testing in immunocompetent mice.
  • Fig. S5. Supporting information for porcine HLI experiments.
  • Table S1. Clinical scoring system for murine limb ischemia morphology.
  • Table S2. White blood cell differential analysis in mice.
  • Table S3. Liver and kidney functions determined by serum biochemistry analysis in mice.
  • Table S4. White blood cell differential analysis in pigs after pegfilgrastim treatment.
  • Legends for movies S1 to S4

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). Extravasation of systemically injected PEG-Qd655 in HA/AGP4-injected site.
  • Movie S2 (.avi format). Extravasation of systemically injected PEG-Qd655 in HA-alone–injected site.
  • Movie S3 (.mp4 format). Three-dimensional reconstructed images of PEG-Qd655 at HA/AGP4-injected site.
  • Movie S4 (.avi format). Three-dimensional reconstructed images of PEG-Qd655 at HA-alone–injected site.