Supplementary Materials

Supplementary Material for:

Oral, ultra–long-lasting drug delivery: Application toward malaria elimination goals

Andrew M. Bellinger, Mousa Jafari, Tyler M. Grant, Shiyi Zhang, Hannah C. Slater, Edward A. Wenger, Stacy Mo, Young-Ah Lucy Lee, Hormoz Mazdiyasni, Lawrence Kogan, Ross Barman, Cody Cleveland, Lucas Booth, Taylor Bensel, Daniel Minahan, Haley M. Hurowitz, Tammy Tai, Johanna Daily, Boris Nikolic, Lowell Wood, Philip A. Eckhoff, Robert Langer,* Giovanni Traverso*

*Corresponding author. Email: rlanger{at}mit.edu (R.L.); ctraverso{at}partners.org (G.T.)

Published 16 November 2016, Sci. Transl. Med. 8, 365ra157 (2016)
DOI: 10.1126/scitranslmed.aag2374

This PDF file includes:

  • Fig. S1. Optimization of elastomer geometry using FEA.
  • Fig. S2. Administration of stellate dosage forms of varying diameters and assessment of the duration of gastric residence.
  • Fig. S3. Mechanical in vitro characterization of gastric residence dosage forms.
  • Fig. S4. Permanent deformation of central elastomer.
  • Fig. S5. Polymeric matrix erosion and diffusion contribute to drug release.
  • Fig. S6. Impact of correlation between treatment rounds for a MDA intervention consisting of DP + 14-day ivermectin at 80% coverage.

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