Supplementary Materials

Supplementary Material for:

Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo

David C. Adams, Lida P. Hariri, Alyssa J. Miller, Yan Wang, Josalyn L. Cho, Martin Villiger, Jasmin A. Holz, Margit V. Szabari, Daniel L. Hamilos, R. Scott Harris, Jason W. Griffith, Brett E. Bouma, Andrew D. Luster, Benjamin D. Medoff, Melissa J. Suter*

*Corresponding author. Email: msuter{at}

Published 5 October 2016, Sci. Transl. Med. 8, 359ra131 (2016)
DOI: 10.1126/scitranslmed.aag1424

This PDF file includes:

  • Supplementary methods on processing techniques and experimental arrangements
  • Fig. S1. Demonstrating OA correction using the endoscopic probe’s sheath.
  • Fig. S2. Uncorrected endoscopic imaging and corrected endoscopic imaging.
  • Fig. S3. Validating OA correction with crossed rubber phantoms.
  • Fig. S4. OA thresholds.
  • Fig. S5. Tissue contour adaptive filtering effect on circumferential OA.
  • Fig. S6. Circularization with refractive index compensation.
  • Fig. S7. Simultaneous force and retardation experimental setup.
  • Fig. S8. Comparison of smooth muscle thicknesses for two tracheal segments used in force experiment.
  • Fig. S9. ASM unwrapping.
  • Table S1. Pertinent subject information from the allergic asthmatic and healthy control subjects in the ASM thickness study.
  • References (3139)

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