Supplementary Materials

Supplementary Material for:

Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria

Sarah J. Higgins, Lisa A. Purcell, Karlee L. Silver, Vanessa Tran, Valerie Crowley, Michael Hawkes, Andrea L. Conroy, Robert O. Opoka, John G. Hay, Susan E. Quaggin, Gavin Thurston, W. Conrad Liles, Kevin C. Kain*

*Corresponding author. Email: kevin.kain{at}

Published 28 September 2016, Sci. Transl. Med. 8, 358ra128 (2016)
DOI: 10.1126/scitranslmed.aaf6812

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Increased Ang-2 expression and circulating Ang-2 and brain Ang-2 protein concentrations are associated with experimental cerebral malaria.
  • Fig. S2. Longitudinal plasma Ang-1 concentrations during experimental cerebral malaria in susceptible mice.
  • Fig. S3. Inhibition of Ang-2 does not alter disease outcome in experimental cerebral malaria.
  • Fig. S4. Comparison of systemic Ang-1 concentrations after adenoviral vector delivery.
  • Fig. S5. Artesunate kinetics and survival in Ang-1–treated mice.

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