Supplementary Materials

Supplementary Material for:

Treatment of otitis media by transtympanic delivery of antibiotics

Rong Yang, Vishakha Sabharwal, Obiajulu S. Okonkwo, Nadya Shlykova, Rong Tong, Lily Yun Lin, Weiping Wang, Shutao Guo, John J. Rosowski, Stephen I. Pelton, Daniel S. Kohane*

*Corresponding author. Email: daniel.kohane{at}childrens.harvard.edu

Published 14 September 2016, Sci. Transl. Med. 8, 356ra120 (2016)
DOI: 10.1126/scitranslmed.aaf4363

This PDF file includes:

  • Materials and Methods
  • Fig. S1. NMR of pentablock copolymers.
  • Fig. S2. Modulation of gelation of aqueous solutions of Cip-[P407-PBP].
  • Fig. S3. Simulation of drug transport across human TMs.
  • Table S1. Molecular weight and polydispersity indices of P407 and pentablock copolymers.
  • Table S2. Systemic exposure to ciprofloxacin by Cip and Cip-3CPE-12%[P407-PBP].
  • Table S3. Apparent diffusion coefficients of Cip and Cip-3CPE-18%[P407-PBP] across healthy and infected human TM.
  • Legend for table S4
  • Legends for movies S1 to S5

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Other Supplementary Material for this manuscript includes the following:

  • Table S4 Tabulated data for Figs. 4 and 5 (provided as an Excel file).
  • Movie S1 (.mp4 format). Gelation of Cip-3CPE-18%[P407] and Cip-3CPE- 18%[P407-PBP].
  • Movie S2 (.mp4 format). Gelation of Cip-18%[P407] and Cip-18%[P407-PBP].
  • Movie S3 (.mp4 format). Extrusion of Cip-3CPE-18%[P407-PBP].
  • Movie S4 (.mp4 format). Extrusion of Cip-3CPE-15%[P407-PBP].
  • Movie S5 (.mp4 format). Extrusion of Cip-3CPE-12%[P407-PBP].