Supplementary Materials

Supplementary Material for:

Insights into neuroepigenetics through human histone deacetylase PET imaging

Hsiao-Ying Wey, Tonya M. Gilbert, Nicole R. Zürcher, Angela She, Anisha Bhanot, Brendan D. Taillon, Fredrick A. Schroeder, Changing Wang, Stephen J. Haggarty, Jacob M. Hooker*

*Corresponding author. Email: hooker{at}nmr.mgh.harvard.edu

Published 10 August 2016, Sci. Transl. Med. 8, 351ra106 (2016)
DOI: 10.1126/scitranslmed.aaf7551

This PDF file includes:

  • Methods
  • Fig. S1. TACs and compartmental model fitting (two-tissue compartmental model) results for superior frontal cortex and white matter.
  • Fig. S2. Stability of outcome measurement (VT) as a function of scan duration.
  • Fig. S3. Regional SUV60-90 min from all brain regions analyzed.
  • Fig. S4. Same day test-retest reproducibility of [11C]Martinostat SUVR60-90 min.
  • Fig. S5. Nuclear density, size, and total area in postmortem baboon brain tissue.
  • Fig. S6. Martinostat thermal shift assay in human SFG and CC biological replicates 1, 2, and 3.
  • Fig. S7. Martinostat thermal shift assay across human gray matter biological replicate 1.
  • Fig. S8. Martinostat thermal shift assay across human gray matter biological replicate 2.
  • Fig. S9. Martinostat thermal shift assay across human gray matter biological replicate 3.
  • Table S1. Biometric information for PET imaging participants.
  • Table S2. Goodness of fit for one- and two-tissue compartmental models to regional PET data.
  • Table S3. Kinetic rate constants and regional VT for [11C]Martinostat.
  • Table S4. Statistical comparison of [11C]Martinostat between different brain regions.
  • Table S5. Sample information for postmortem human brain tissue.

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