Supplementary Materials

Supplementary Material for:

Imaging synaptic density in the living human brain

Sjoerd J. Finnema,* Nabeel B. Nabulsi, Tore Eid, Kamil Detyniecki, Shu-fei Lin, Ming-Kai Chen, Roni Dhaher, David Matuskey, Evan Baum, Daniel Holden, Dennis D. Spencer, Joël Mercier, Jonas Hannestad, Yiyun Huang, Richard E. Carson

*Corresponding author. Email: sjoerd.finnema{at}yale.edu

Published 20 July 2016, Sci. Transl. Med. 8, 348ra96 (2016)
DOI: 10.1126/scitranslmed.aaf6667

This PDF file includes:

  • Methods
  • Fig. S1. Saturation studies of [11C]UCB-J in regions of the baboon brain.
  • Fig. S2. Scatchard plots of [11C]UCB-J in regions of the baboon brain.
  • Fig. S3. PET summation images after bolus injection of [11C]UCB-J in healthy human subjects.
  • Fig. S4. Regional TACs after bolus injection of [11C]UCB-J in healthy human subjects.
  • Fig. S5. Regional TACs of VT values after bolus plus constant infusion of [11C]UCB-J in additional healthy human subjects.
  • Fig. S6. PET summation images after bolus plus constant infusion of [11C]UCB-J in human subjects.
  • Table S1. Unchanged [11C]UCB-J fraction in plasma in five control subjects evaluated with bolus injection of [11C]UCB-J.
  • Table S2. Plasma free fraction of [11C]UCB-J in five control subjects evaluated with bolus injection of [11C]UCB-J.
  • Table S3. Regional VT values after bolus injection of [11C]UCB-J in five control subjects.
  • Table S4. Regional K1 values after bolus injection of [11C]UCB-J in five control subjects.
  • Table S5. BPND values after bolus injection of [11C]UCB-J in five control subjects.
  • References (5457)

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