Supplementary Materials

Supplementary Material for:

Low α-defensin gene copy number increases the risk for IgA nephropathy and renal dysfunction

Zhen Ai, Ming Li, Wenting Liu, Jia-Nee Foo, Omniah Mansouri, Peiran Yin, Qian Zhou, Xueqing Tang, Xiuqing Dong, Shaozhen Feng, Ricong Xu, Zhong Zhong, Jian Chen, Jianxin Wan, Tanqi Lou, Jianwen Yu, Qin Zhou, Jinjin Fan, Haiping Mao, Daniel Gale, Jonathan Barratt, John A. L. Armour, Jianjun Liu,* Xueqing Yu*

*Corresponding author. Email: yuxq{at}mail.sysu.edu.cn (X.Y.); liuj3{at}gis.a-star.edu.sg (J.L.)

Published 29 June 2016, Sci. Transl. Med. 8, 345ra88 (2016)
DOI: 10.1126/scitranslmed.aaf2106

This PDF file includes:

  • Methods
  • Fig. S1. Schematic map of the DEFA1A3 CNV.
  • Fig. S2. Distribution of DEFA1A3 CNVs in the combined Chinese IgAN cohort.
  • Fig. S3. Correlation of the DEFA1A3 copy numbers measured by two methods.
  • Fig. S4. Distribution of GSs in the combined Chinese IgAN cohorts.
  • Fig. S5. Distribution of the average copy numbers of DEFA1A3 CNVs according to the genotypes of rs2738048 in the combined Chinese IgAN cohorts.
  • Fig. S6. Distribution of three risk variants of DEFA1A3 CNVs in the Caucasian IgAN cohort (531 cases and 198 controls) and Chinese IgAN cohorts (1189 cases and 1187 controls).
  • Fig. S7. Serum IgA1 and proportion of galactose-deficient IgA1.
  • Table S1. Summary of the study cohorts for the DEFA1A3 CNVs association analysis.
  • Table S2. Copy number distribution of DEFA1A3 CNVs in the combined IgAN cohorts (1189 cases and 1187 controls).
  • Table S3. Spearman correlation analysis between DEFA1A3 CNVs and SNPs in the combined Chinese IgAN cohorts (1189 cases and 1187 controls).
  • Table S4. Logistic regression analysis of DEFA1A3 CNVs and SNPs in the two independent Chinese IgAN cohorts.
  • Table S5. Interaction analysis of three DEFA1A3 CNVs in the combined Chinese IgAN cohorts (1189 cases and 1187 controls).
  • Table S6. Comparison of the copy numbers of DEFA1A3 CNVs between cases and controls in the combined Chinese IgAN cohorts.
  • Table S7. The clinical and pathological features at the time of diagnosis for 1189 Chinese IgAN patients.
  • Table S8. Association analysis between the GSs of DEFA1A3 CNVs and clinicopathologic features in 1189 Chinese IgAN patients.
  • Table S9. Logistic regression analysis of rs2738048, rs12716641, and DEFA1A3 CNVs in the combined Chinese IgAN cohort (1189 cases and 1187 controls).
  • Table S10. Multivariate linear regression analysis between serum HNP1–3, urine HNP1–3, neutrophil extracellular HNP1–3 (LPS-stimulated), and DEFA1A3 CNVs.
  • Table S11. Linear regression analysis of serum IgA1 and proportion of galactose-deficient IgA1 with the copy numbers of DEFA1A3 CNVs in 158 subjects.

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