Supplementary Materials

Supplementary Material for:

Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability

Moran Yassour, Tommi Vatanen, Heli Siljander, Anu-Maaria Hämäläinen, Taina Härkönen, Samppa J. Ryhänen, Eric A. Franzosa, Hera Vlamakis, Curtis Huttenhower, Dirk Gevers, Eric S. Lander, Mikael Knip, on behalf of the DIABIMMUNE Study Group, Ramnik J. Xavier*

*Corresponding author. Email: xavier{at}

Published 15 June 2016, Sci. Transl. Med. 8, 343ra81 (2016)
DOI: 10.1126/scitranslmed.aad0917

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Average relative abundance of dominant genera in all 39 children.
  • Fig. S2. Bifidobacterium abundance together with early feeding data.
  • Fig. S3. Individual profiles of Bacteroides abundance together with solid food consumption.
  • Fig. S4. Consistency of the infant gut microbiome.
  • Fig. S5. Microbial trajectories for all children in the study.
  • Fig. S6. Richness of the infant gut microbiome.
  • Fig. S7. Strain similarity patterns of abundant species.
  • Fig. S8. Strain diversity.
  • Fig. S9. Stability of the infant gut microbiome.
  • Fig. S10. Abundance profiles for antibiotic resistance genes.
  • Legend for table S1
  • List of investigators in the DIABIMMUNE Study Group.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Clinical variables used in this study including birth mode, early feeding history, and antibiotic treatments.