Supplementary Materials

Supplementary Material for:

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Robert A. Scott,* Daniel F. Freitag, Li Li, Audrey Y. Chu, Praveen Surendran, Robin Young, Niels Grarup, Alena Stancáková, Yuning Chen, Tibor V. Varga, Hanieh Yaghootkar, Jian'an Luan, Jing Hua Zhao, Sara M. Willems, Jennifer Wessel, Shuai Wang, Nisa Maruthur, Kyriaki Michailidou, Ailith Pirie, Sven J. van der Lee, Christopher Gillson, Ali Amin Al Olama, Philippe Amouyel, Larraitz Arriola, Dominique Arveiler, Iciar Aviles-Olmos, Beverley Balkau, Aurelio Barricarte, Inês Barroso, Sara Benlloch Garcia, Joshua C. Bis, Stefan Blankenberg, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Ingrid B. Borecki, Jette Bork-Jensen, Sarah Bowden, Carlos Caldas, Muriel Caslake, The CVD50 consortium, L. Adrienne Cupples, Carlos Cruchaga, Jacek Czajkowski, Marcel den Hoed, Janet A. Dunn, Helena M. Earl, Georg B. Ehret, Ele Ferrannini, Jean Ferrieres, Thomas Foltynie, Ian Ford, Nita G. Forouhi, Francesco Gianfagna, Carlos Gonzalez, Sara Grioni, Louise Hiller, Jan-Håkan Jansson, Marit E. Jørgensen, J. Wouter Jukema, Rudolf Kaaks, Frank Kee, Nicola D. Kerrison, Timothy J. Key, Jukka Kontto, Zsofia Kote-Jarai, Aldi T. Kraja, Kari Kuulasmaa, Johanna Kuusisto, Allan Linneberg, Chunyu Liu, Gaëlle Marenne, Karen L. Mohlke, Andrew P. Morris, Kenneth Muir, Martina Müller-Nurasyid, Patricia B. Munroe, Carmen Navarro, Sune F. Nielsen, Peter M. Nilsson, Børge G. Nordestgaard, Chris J. Packard, Domenico Palli, Salvatore Panico, Gina M. Peloso, Markus Perola, Annette Peters, Christopher J. Poole, J. Ramón Quirós, Olov Rolandsson, Carlotta Sacerdote, Veikko Salomaa, María-José Sánchez, Naveed Sattar, Stephen J. Sharp, Rebecca Sims, Nadia Slimani, Jennifer A. Smith, Deborah J. Thompson, Stella Trompet, Rosario Tumino, Daphne L. van der A, Yvonne T. van der Schouw, Jarmo Virtamo, Mark Walker, Klaudia Walter, GERAD_EC Consortium, Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), Alzheimer's Disease Genetics Consortium, Pancreatic Cancer Cohort Consortium, European Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD), EPIC-InterAct, Jean E. Abraham, Laufey T. Amundadottir, Jennifer L. Aponte, Adam S. Butterworth, Josée Dupuis, Douglas F. Easton, Rosalind A. Eeles, Jeanette Erdmann, Paul W. Franks, Timothy M. Frayling, Torben Hansen, Joanna M. M. Howson, Torben Jørgensen, Jaspal Kooner, Markku Laakso, Claudia Langenberg, Mark I. McCarthy, James S. Pankow, Oluf Pedersen, Elio Riboli, Jerome I. Rotter, Danish Saleheen, Nilesh J. Samani, Heribert Schunkert, Peter Vollenweider, Stephen O'Rahilly, CHARGE consortium, The CHD Exome+ Consortium, CARDIOGRAM Exome Consortium, Panos Deloukas, John Danesh, Mark O. Goodarzi, Sekar Kathiresan, James B. Meigs, Margaret G. Ehm, Nicholas J. Wareham,* Dawn M. Waterworth*

*Corresponding author. Email: dawn.m.waterworth{at}gsk.com (D.M.W.); robert.scott{at}mrc-epid.cam.ac.uk (R.A.S.); nick.wareham{at}mrc-epid.cam.ac.uk (N.J.W.)

Published 1 June 2016, Sci. Transl. Med. 8, 341ra76 (2016)
DOI: 10.1126/scitranslmed.aad3744

This PDF file includes:

  • Additional acknowledgments and funding
  • Methods
  • Fig. S1. Effects of GLP1R agonists on body weight.
  • Fig. S2. Effects of GLP1R agonists on 2-hour glucose.
  • Legend for table S1
  • Table S2. Comparison of heterogeneity between trial and rescaled genetic estimates.
  • Legends for tables S3 and S4
  • References (51115)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Study characteristics for disease traits.
  • Table S3 (Microsoft Excel format). Details of randomized trials contributing to analyses of GLP1R agonist effects included in Fig. 2.
  • Table S4 (Microsoft Excel format). Study characteristics for quantitative traits.

[Download Tables S1, S3, and S4]