Supplementary Materials

Supplementary Material for:

Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform

Ali Zarrinpar,* Dong-Keun Lee, Aleidy Silva, Nakul Datta, Theodore Kee, Calvin Eriksen, Keri Weigle, Vatche Agopian, Fady Kaldas, Douglas Farmer, Sean E. Wang, Ronald Busuttil, Chih-Ming Ho,* Dean Ho*

*Corresponding author. E-mail: azarrinpar{at}mednet.ucla.edu (A.Z.); chihming{at}g.ucla.edu (C.-M.H.); dean.ho{at}ucla.edu (D.H.)

Published 6 April 2016, Sci. Transl. Med. 8, 333ra49 (2016)
DOI: 10.1126/scitranslmed.aac5954

This PDF file includes:

  • Subject clinical details
  • Methods
  • Fig. S1. The effect of cotrimoxazole and fluconazole dosing on patients’ trough levels.
  • Fig. S2. PPD tacrolimus-prednisone interaction plots for patients PPD1, PPD2, and C1.
  • Fig. S3. PPD tacrolimus-cotrimoxazole interaction plots for patient PPD4.
  • Fig. S4. Retrospective PPD-guided tacrolimus and prednisone dosing optimization for patients C1 and C2.
  • Table S1. Clinical summaries of control patients (C1 to C4) and PPD-guided patients (PPD1 to PPD4).
  • Table S2. Data used for statistical comparisons in Fig. 5.
  • Table S3. Patient-specific antibiotic and antifungal dosing changes and corresponding tacrolimus trough levels.
  • Table S4. Patient-specific anti-inflammatory and immunosuppressant dosing changes and corresponding trough levels.

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). Introduction to PPD and patient recalibration.
  • Movie S2 (.mov format). Patient PPD2 recalibration tutorial.
  • Movie S3 (.mov format). Patient PPD3 recalibration tutorial.