Supplementary Materials

Supplementary Material for:

Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity

Jin-Chong Xu, Jing Fan, Xueqing Wang, Stephen M. Eacker, Tae-In Kam, Li Chen, Xiling Yin, Juehua Zhu, Zhikai Chi, Haisong Jiang, Rong Chen, Ted M. Dawson,* Valina L. Dawson*

*Corresponding author. E-mail: vdawson{at}jhmi.edu (V.L.W.); tdawson{at}jhmi.edu (T.M.W.)

Published 6 April 2016, Sci. Transl. Med. 8, 333ra48 (2016)
DOI: 10.1126/scitranslmed.aad0623

This PDF file includes:

  • Fig. S1. Comparison of human forebrain neuron differentiation method.
  • Fig. S2. Neural induction of human iPSCs by dual inhibition of SMAD signaling enhances the efficiency of neural conversion via the RONA method.
  • Fig. S3. Isolated FOXG1+ forebrain progenitors preserve excitatory and inhibitory neurogenic potential.
  • Fig. S4. Development regulates the excitatory/inhibitory network formation and synaptic scaling.
  • Fig. S5. NMDA induces human cortical neuron cell death.
  • Fig. S6. PARP activation in male versus female human ESCs.

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Other Supplementary Material for this manuscript includes the following: