Supplementary Materials

Supplementary Material for:

Somatic PIK3CA mutations as a driver of sporadic venous malformations

Pau Castel, F. Javier Carmona, Joaquim Grego-Bessa, Michael F. Berger, Agnès Viale, Kathryn V. Anderson, Silvia Bague, Maurizio Scaltriti, Cristina R. Antonescu, Eulàlia Baselga, José Baselga*

*Corresponding author. E-mail: baselgaj{at}

Published 30 March 2016, Sci. Transl. Med. 8, 332ra42 (2016)
DOI: 10.1126/scitranslmed.aaf1164

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Histologic characterization of PIK3CASprr2f-Cre mice.
  • Fig. S2. PIK3CA mutation in ECs.
  • Fig. S3. Histologic characterization of PIK3CACAG-CreER mice.
  • Fig. S4. Histologic characterization of PIK3CAUBC-CreER mice.
  • Fig. S5. Cell proliferation in mouse VM with or without in vivo treatments.
  • Fig. S6. Treatment of VM with PI3K inhibitors.
  • Fig. S7. Histological assessment of PIK3CATie2-Cre embryos.
  • Table S1. Clinical features and genomic findings in VM patients.
  • Table S2. Bait sequences used for TEK targeted sequencing.

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