Supplementary Materials

Supplementary Material for:

Targeting protein homeostasis in sporadic inclusion body myositis

Mhoriam Ahmed, Pedro M. Machado, Adrian Miller, Charlotte Spicer, Laura Herbelin, Jianghua He, Janelle Noel, Yunxia Wang, April L. McVey, Mamatha Pasnoor, Philip Gallagher, Jeffrey Statland, Ching-Hua Lu, Bernadett Kalmar, Stefen Brady, Huma Sethi, George Samandouras, Matt Parton, Janice L. Holton, Anne Weston, Lucy Collinson, J. Paul Taylor, Giampietro Schiavo, Michael G. Hanna, Richard J. Barohn, Mazen M. Dimachkie,* Linda Greensmith*

*Corresponding author. E-mail: l.greensmith{at}ucl.ac.uk (L.G.); mdimachkie{at}kumc.edu (M.M.D.)

Published 23 March 2016, Sci. Transl. Med. 8, 331ra41 (2016)
DOI: 10.1126/scitranslmed.aad4583

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Overexpression of β-APP and exposure to inflammatory mediators induce sIBM-like pathology in cultured myocytes.
  • Fig. S2. Mutant VCP mice show further signs of pathology.
  • Fig. S3. Consort diagram of the patients participating in the clinical trial.
  • Table S1. Baseline characteristics of the study population.
  • Table S2. Summary of all adverse events over the course of 1 year.
  • Table S3. Mean changes (±SD) in secondary outcome measures throughout the study period.
  • Legends for movies S1 to S4
  • References (59, 60)

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). Low-magnification serial block-face scanning electron microscopy of arimoclomol-treated and untreated mutant VCP mouse muscle.
  • Movie S2 (.mov format). High-magnification serial block-face scanning electron microscopy of wild-type VCP mouse muscle.
  • Movie S3 (.mov format). High-magnification serial block-face scanning electron microscopy of untreated mutant VCP mouse muscle.
  • Movie S4 (.mov format). High-magnification serial block-face scanning electron microscopy of arimoclomol-treated mutant VCP mouse muscle.