Supplementary Materials

Supplementary Material for:

Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

Zhen Yang, Yi Shen, Hisashi Oishi, Eric L. Matteson, Lu Tian, Jörg J. Goronzy, Cornelia M. Weyand*

*Corresponding author. E-mail: cweyand{at}

Published 23 March 2016, Sci. Transl. Med. 8, 331ra38 (2016)
DOI: 10.1126/scitranslmed.aad7151

This PDF file includes:

  • Fig. S1. G6PD is regulated by T cell stimulation.
  • Fig. S2. The impact of therapy on G6PD expression in RA T cells.
  • Fig. S3. Intracellular GSH in resting naïve and memory T cells.
  • Fig. S4. G6PD protein expression in RA T cells transfected with gene-specific siRNA.
  • Fig. S5. Reconstitution of NSG mice with human T cells.
  • Fig. S6. Autologous monocytes are required for the expansion of human T cells in NSG hosts.
  • Fig. S7. BSO increases intracellular ROS in RA T cells.
  • Table S1. Demographic and clinical characteristics of the study population.
  • Table S2. List of primers.

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