Supplementary Materials

Supplementary Material for:

Chronic skin inflammation leads to bone loss by IL-17–mediated inhibition of Wnt signaling in osteoblasts

Özge Uluçkan, Maria Jimenez, Susanne Karbach, Anke Jeschke, Osvaldo Graña, Johannes Keller, Björn Busse, Andrew L. Croxford, Stephanie Finzel, Marije Koenders, Wim van den Berg, Thorsten Schinke, Michael Amling, Ari Waisman, Georg Schett, Erwin F. Wagner*

*Corresponding author. E-mail: ewagner{at}

Published 16 March 2016, Sci. Transl. Med. 8, 330ra37 (2016)
DOI: 10.1126/scitranslmed.aad8996

This PDF file includes:

  • Materials and Methods
  • Fig. S1. IL-17A expression in skin, lymph nodes, and bone marrow of JunBΔep mice.
  • Fig. S2. IL-17A expression in ILCs in K14-IL17Aind mice.
  • Fig. S3. Bone parameters of JunBΔep mice at 3 and 6 months of age.
  • Fig. S4. IL-17A does not affect osteoclast differentiation in vitro.
  • Fig. S5. Sclerostin levels are not up-regulated by IL-17A.
  • Fig. S6. NFκB is phosphorylated upon IL-17A treatment in BMSCs.
  • Fig. S7. Gating strategies for T cells, γδ T cells, and ILCs expressing IL-17A.
  • Fig. S8. Unmodified complete Western blots.
  • References (4758)

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Other Supplementary Material for this manuscript includes the following: