Supplementary Materials

Supplementary Material for:

Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment

Suming Wang, Anna Blois, Tina El Rayes, Joyce F. Liu, Michelle S. Hirsch, Karsten Gravdal, Sangeetha Palakurthi, Diane R. Bielenberg, Lars A. Akslen, Ronny Drapkin, Vivek Mittal, Randolph S. Watnick*

*Corresponding author. E-mail: randy.watnick{at}childrens.harvard.edu

Published 9 March 2016, Sci. Transl. Med. 8, 329ra34 (2016)
DOI: 10.1126/scitranslmed.aad5653

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Expression of CD36 in patient-derived ovarian cancer cells.
  • Fig. S2. FACS analysis of rhTSP-1 effects on ovarian cancer cell apoptosis.
  • Fig. S3. Effects of CD36 blocking antibody on rhTSP-1 induction of ovarian cancer cell apoptosis.
  • Fig. S4. Body weight tracking of mice bearing patient-derived ovarian cancer metastases.
  • Fig. S5. Bioluminescent imaging of peptide-treated patient-derived ovarian cancer metastases.
  • Fig. S6. Bioluminescent imaging of control-treated patient-derived ovarian cancer metastases.
  • Fig. S7. CD36 staining of ovarian cancer patient TMA.
  • Table S1. Characterization of platinum sensitivity of patient-derived ovarian cancer cells.
  • References (38, 39)

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Other Supplementary Material for this manuscript includes the following:

  • Table S2 Original data (provided as an Excel file).