Supplementary Material for:

Chronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-Pick type C disease in a mouse model

Md. Suhail Alam, Michelle Getz, Kasturi Haldar*

*Corresponding author. E-mail: khaldar{at}nd.edu

Published 17 February 2016, Sci. Transl. Med. 8, 326ra23 (2016)
DOI: 10.1126/scitranslmed.aad9407

This PDF file includes:

• Materials and Methods
• Fig. S1. Baseline acetylation of histones in mouse brain tissue.
• Fig. S2. Nissl staining of mouse brain sections.
• Fig. S3. Quantitative analyses of brain inflammation.
• Fig. S4. Comparative analysis of survival between mice treated with TCF and those treated with HPBCD + vehicle.
• Fig. S5. Comparison of disease severity progression curves by two independent operators.
• Fig. S6. Histological analysis of liver from mice treated long-term with TCF.
• Fig. S7. Generalized model for TCF in treating cerebral and systemic disease.
• Table S1. List of parameters used to score the neurobehavioral functions of Npc mice.

[Download PDF]