Supplementary Materials

Supplementary Material for:

Chronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-Pick type C disease in a mouse model

Md. Suhail Alam, Michelle Getz, Kasturi Haldar*

*Corresponding author. E-mail: khaldar{at}

Published 17 February 2016, Sci. Transl. Med. 8, 326ra23 (2016)
DOI: 10.1126/scitranslmed.aad9407

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Baseline acetylation of histones in mouse brain tissue.
  • Fig. S2. Nissl staining of mouse brain sections.
  • Fig. S3. Quantitative analyses of brain inflammation.
  • Fig. S4. Comparative analysis of survival between mice treated with TCF and those treated with HPBCD + vehicle.
  • Fig. S5. Comparison of disease severity progression curves by two independent operators.
  • Fig. S6. Histological analysis of liver from mice treated long-term with TCF.
  • Fig. S7. Generalized model for TCF in treating cerebral and systemic disease.
  • Table S1. List of parameters used to score the neurobehavioral functions of Npc mice.

[Download PDF]