Supplementary Materials
Supplementary Material for:
Chronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-Pick type C disease in a mouse model
Md. Suhail Alam, Michelle Getz, Kasturi Haldar*
*Corresponding author. E-mail: khaldar{at}nd.edu
Published 17 February 2016, Sci. Transl. Med. 8, 326ra23 (2016)
DOI: 10.1126/scitranslmed.aad9407
This PDF file includes:
- Materials and Methods
- Fig. S1. Baseline acetylation of histones in mouse brain tissue.
- Fig. S2. Nissl staining of mouse brain sections.
- Fig. S3. Quantitative analyses of brain inflammation.
- Fig. S4. Comparative analysis of survival between mice treated with TCF and those treated with HPBCD + vehicle.
- Fig. S5. Comparison of disease severity progression curves by two independent operators.
- Fig. S6. Histological analysis of liver from mice treated long-term with TCF.
- Fig. S7. Generalized model for TCF in treating cerebral and systemic disease.
- Table S1. List of parameters used to score the neurobehavioral functions of Npc mice.