Supplementary Materials

Supplementary Material for:

Pacemaker-induced transient asynchrony suppresses heart failure progression

Jonathan A. Kirk, Khalid Chakir, Kyoung Hwan Lee, Edward Karst, Ronald J. Holewinski, Gianluigi Pironti, Richard S. Tunin, Iraklis Pozios, Theodore P. Abraham, Pieter de Tombe, Howard A. Rockman, Jennifer E. Van Eyk, Roger Craig, Taraneh G. Farazi, David A. Kass*

*Corresponding author. E-mail: dkass{at}

Published 23 December 2015, Sci. Transl. Med. 7, 319ra207 (2015)
DOI: 10.1126/scitranslmed.aad2899

This PDF file includes:

  • Methods
  • Fig. S1. Holter monitoring confirmed atrial pacing during the day and ventricular pacing at night.
  • Fig. S2. β-Adrenergic response in HF and PITA.
  • Fig. S3. β2AR stimulation revealed little improvement in PITA.
  • Fig. S4. Western blots of βAR signaling.
  • Fig. S5. Changes in βAR density were not due to mRNA expression of GRK signaling.
  • Fig. S6. Holter monitoring confirmed randomly distributed 2-min periods of right ventricular pacing.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). SWATH MS protein areas for each sample, normalized to βMHC