Supplementary Materials

Supplementary Material for:

Improving the spatial resolution of epiretinal implants by increasing stimulus pulse duration

Andrew C. Weitz, Devyani Nanduri, Matthew R. Behrend, Alejandra Gonzalez-Calle, Robert J. Greenberg, Mark S. Humayun, Robert H. Chow,* James D. Weiland*

*Corresponding author. E-mail: jweiland{at}med.usc.edu (J.D.W.); rchow{at}med.usc.edu (R.H.C.)

Published 16 December 2015, Sci. Transl. Med. 7, 318ra203 (2015)
DOI: 10.1126/scitranslmed.aac4877

This PDF file includes:

  • Results
  • Fig. S1. Selectivity ratios (mean axon threshold divided by mean soma threshold) for different stimulus pulse durations.
  • Fig. S2. Strength-duration curves for 200-μm-diameter electrodes.
  • Fig. S3. Multielectrode stimulation of RGCs with synchronous pulses.
  • Fig. S4. Multielectrode stimulation of RGCs with temporally interleaved pulses.
  • Fig. S5. Charge injection limits for short and long pulses.
  • Table S1. Electrical stimulation parameters used in the single-electrode calcium imaging experiments.
  • Table S2. Number of retinas and RGCs that make up each threshold map.
  • Table S3. Comparison of thresholds in wild-type and RD retinas for three pulse widths.
  • Table S4. Effect of stimulus pulse duration on phosphene elongation in a retinal prosthesis subject.
  • Legends for movies S1 and S2
  • Reference (50)

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1. (.mov format). Single-electrode stimulation with 1-ms pulses.
  • Movie S2 Multielectrode stimulation with 25-ms pulses.