Supplementary Materials

Supplementary Material for:

Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging

Ingo Stoffels, Stefan Morscher, Iris Helfrich, Uwe Hillen, Julia Leyh, Neal C. Burton, Thomas C. P. Sardella, Jing Claussen, Thorsten D. Poeppel, Hagen S. Bachmann, Alexander Roesch, Klaus Griewank, Dirk Schadendorf, Matthias Gunzer, Joachim Klode*

*Corresponding author. E-mail: joachim.klode{at}

Published 9 December 2015, Sci. Transl. Med. 7, 317ra199 (2015)
DOI: 10.1126/scitranslmed.aad1278

This PDF file includes:

  • Methods
  • Fig. S1. Detection limit and signal linearity of MSOT inVision imaging system in phantoms.
  • Fig. S2. Characteristics of the ultrasound detectors, as specified by the manufacturer.
  • Fig. S3. Multispectral image composition.
  • Table S1. Characteristics of 214 melanoma patients in the preclinical ex vivo cohort.
  • Table S2. Patient characteristics of the clinical in vivo cohort.
  • Legends for movies S1 to S4

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). Flythrough ex vivo lymph node.
  • Movie S2 (.avi format). In vivo image sequence of lymph vessels and lymph node.
  • Movie S3 (.avi format). Rotating 3D rendering of an ICG-containing lymph node.
  • Movie S4 (.mpg format). Sequence of cross-sectional images obtained from an excised lymph node with a hypopigmented melanoma metastasis.