Supplementary Materials

Supplementary Material for:

Riluzole blocks perioperative ischemia-reperfusion injury and enhances postdecompression outcomes in cervical spondylotic myelopathy

Spyridon K. Karadimas, Alex M. Laliberte, Lindsay Tetreault, Young Sun Chung, Paul Arnold, Warren D. Foltz, Michael G. Fehlings*

*Corresponding author. E-mail: michael.fehlings{at}uhn.ca

Published 2 December 2015, Sci. Transl. Med. 7, 316ra194 (2015)
DOI: 10.1126/scitranslmed.aac6524

This PDF file includes:

  • Fig. S1. Percentage of patients who underwent surgical decompression at various cervical levels.
  • Fig. S2. Surgical decompression of the rat cervical spinal cord.
  • Fig. S3. Blood flow assessment before and after surgical decompression using FAIR MRI.
  • Fig. S4. Combination treatment promoted robust axonal preservation of the main CST.
  • Fig. S5. Combination treatment attenuated below-level neuropathic pain behaviors.
  • Fig. S6. Combination treatment decreased microglia recruitment in the lumbar dorsal horns of CSM rats.
  • Table S1. mJOA classification scoring.
  • Legends for movies S1 and S2

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). 3D reconstruction of the cervical spinal cord segment used for stereological estimation of the proportion of preserved neurons undergoing oxidative damage in the decompression group.
  • Movie S2 (.mov format). 3D reconstruction of the cervical spinal cord segment used for stereological estimation of the proportion of preserved neurons undergoing oxidative damage in the decompression-riluzole group.