Supplementary Materials

Supplementary Material for:

The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis

Jinkuk Choi, Jie Gao, Jaekwang Kim, Cynthia Hong, Jungsu Kim,* Peter Tontonoz*

*Corresponding author. E-mail: ptontonoz{at}mednet.ucla.edu (P.T.); kim.jungsu{at}mayo.edu (J.K.)

Published 18 November 2015, Sci. Transl. Med. 7, 314ra184 (2015)
DOI: 10.1126/scitranslmed.aad1904

This PDF file includes:

  • Fig. S1. Idol decreases LDLR protein and promotes LDLR ubiquitination in mouse brain cells.
  • Fig. S2. Loss of Idol does not directly affect inflammatory responses.
  • Fig. S3. Idol inhibition promotes the clearance of Aβby microglia.
  • Table S1. Data for Aβ40 shown in Fig. 2A.
  • Table S2. Data for Aβ42 shown in Fig. 2A.
  • Table S3. Quantification of Aβ plaque load in Fig. 2E.
  • Table S4. Quantification of thioflavin S plaque load in Fig. 3B.
  • Table S5. Quantification of CD45 load in Fig. 4B.
  • Table S6. Quantification of Iba+ cells in Fig. 4D.

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