Supplementary Materials

Supplementary Material for:

Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle

Miles A. Miller, Suresh Gadde, Christina Pfirschke, Camilla Engblom, Melissa M. Sprachman, Rainer H. Kohler, Katherine S. Yang, Ashley M. Laughney, Gregory Wojtkiewicz, Nazila Kamaly, Sushma Bhonagiri, Mikael J. Pittet, Omid C. Farokhzad,* Ralph Weissleder*

*Corresponding author. E-mail: rweissleder{at}mgh.harvard.edu (R.W.); ofarokhzad{at}bwh.harvard.edu (O.C.F)

Published 18 November 2015, Sci. Transl. Med. 7, 314ra183 (2015)
DOI: 10.1126/scitranslmed.aac6522

This PDF file includes:

  • Methods
  • Fig. S1. Fluorescent NP synthesis and characterization.
  • Fig. S2. Imaging single-cell kinetics of MNP distribution with no TNP/MNP fluorescence spectral bleed-through.
  • Fig. S3. MNP matches TNP plasma kinetics and does not influence TNP uptake.
  • Fig. S4. MNP and TNP uptake by perivascular host cells in ovarian cancer.
  • Fig. S5. MNP uptake in tumor-associated Cx3cr1+ host cells.
  • Fig. S6. Imaging cytometric analysis of single-cell NP distribution kinetics.
  • Fig. S7. MNPs colocalize with liposomes in tumor-associated cells.
  • Fig. S8. Characterization of paclitaxel-loaded TNP and fluorescent derivatives.
  • Table S1. Optimized finite-element method modeling parameters and reference values.
  • References (3338)

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