Supplementary Materials

Supplementary Material for:

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma

Daniel R. Carter, Jayne Murray, Belamy B. Cheung, Laura Gamble, Jessica Koach, Joanna Tsang, Selina Sutton, Heyam Kalla, Sarah Syed, Andrew J. Gifford, Natalia Issaeva, Asel Biktasova, Bernard Atmadibrata, Yuting Sun, Nicolas Sokolowski, Dora Ling, Patrick Y. Kim, Hannah Webber, Ashleigh Clark, Michelle Ruhle, Bing Liu, André Oberthuer, Matthias Fischer, Jennifer Byrne, Federica Saletta, Le Myo Thwe, Andrei Purmal, Gary Haderski, Catherine Burkhart, Frank Speleman, Katleen De Preter, Anneleen Beckers, David S. Ziegler, Tao Liu, Katerina V. Gurova, Andrei V. Gudkov, Murray D. Norris, Michelle Haber,* Glenn M. Marshall*

*Corresponding author. E-mail: g.marshall{at}unsw.edu.au (G.M.M.); mhaber{at}ccia.unsw.edu.au (M.H.)

Published 4 November 2015, Sci. Transl. Med. 7, 312ra176 (2015)
DOI: 10.1126/scitranslmed.aab1803

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Data supporting Fig. 1.
  • Fig. S2. Data supporting Fig. 2.
  • Fig. S3. Data supporting Fig. 3.
  • Fig. S4. Data supporting Fig. 4.
  • Fig. S5. Data supporting Fig. 5.
  • Fig. S6. Data supporting Fig. 6.
  • Fig. S7. Data supporting Fig. 7.
  • Fig. S8. Fluorescence in situ hybridization for MYCN amplification in tissue microarray.
  • Table S1. Cox proportional hazards modeling of MYC target signature members in 649 neuroblastoma patients.
  • Table S2. Literature analysis of lead candidates that favor poor outcome in neuroblastoma.
  • Table S3. Cox proportional hazards modeling of SSRP1 and SPT16 in 649 neuroblastoma patients.
  • Table S4. Gene set enrichment analysis of 2-week-old TH-MYCN+/+ ganglia compared with age-matched wild-type mice.
  • Table S5. Histology of TH-MYCN+/+ mice treated with oral or intravenous CBL0137.
  • Table S6. Histology of TH-MYCN+/+ mice treated with a dose-escalating regimen of intravenous CBL0137.
  • Table S7. P values not shown in figures.
  • References (4459)

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