Supplementary Materials

Supplementary Material for:

Inflammation activation and resolution in human tendon disease

Stephanie G. Dakin,* Fernando O. Martinez, Clarence Yapp, Graham Wells, Udo Oppermann, Benjamin J. F. Dean, Richard D. J. Smith, Kim Wheway, Bridget Watkins, Lucy Roche, Andrew J. Carr

*Corresponding author. E-mail: stephanie.dakin{at}ndorms.ox.ac.uk

Published 28 October 2015, Sci. Transl. Med. 7, 311ra173 (2015)
DOI: 10.1126/scitranslmed.aac4269

This PDF file includes:

  • Fig. S1. NF-κB–p65 staining in diseased human supraspinatus tendons.
  • Fig. S2. Phosphorylated STAT-6 staining in diseased human supraspinatus tendons.
  • Fig. S3. Gene expression signatures after treating tendon-derived stromal cell–macrophage cocultures with IFNγ, LPS, or IL-13 for 96 hours.
  • Fig. S4. Expression of IFN activation pathway genes in biopsies from patients with early-stage tendon disease before and after surgical subacromial decompression treatment.
  • Fig. S5. Isotype control staining of diseased human supraspinatus tendons.
  • Legends for tables S1 and S2
  • Table S3. Primary antibodies used for immunohistochemistry and immunofluorescence.

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Primer sequences and validation for qPCR.
  • Table S2 (Microsoft Excel format). Summary of inflammation activation pathway gene signatures in samples of early-, intermediate-, and advanced-stage diseased human supraspinatus tendons.

[Download Tables S1 and S2]