Supplementary Materials

Supplementary Material for:

Ultrasound-mediated gastrointestinal drug delivery

Carl M. Schoellhammer, Avi Schroeder, Ruby Maa, Gregory Yves Lauwers, Albert Swiston, Michael Zervas, Ross Barman, Angela M. DiCiccio, William R. Brugge, Daniel G. Anderson, Daniel Blankschtein,* Robert Langer,* Giovanni Traverso*

*Corresponding author. E-mail: dblank{at}mit.edu (D.B.); rlanger{at}mit.edu (R.L.); ctraverso{at}partners.org (G.T.)

Published 21 October 2015, Sci. Transl. Med. 7, 310ra168 (2015)
DOI: 10.1126/scitranslmed.aaa5937

This PDF file includes:

  • Supplementary Methods
  • Fig. S1. Glucose, inulin, and hydrocortisone uptake in GI tissues ex vivo.
  • Fig. S2. Distribution of permeants between porcine colonic tissue and the receiver chamber ex vivo.
  • Fig. S3. Permeability of the porcine small intestine to glucose and inulin.
  • Fig. S4. Tolerability of rectal ultrasound in healthy mouse and pig models.
  • Fig. S5. Representative NMR spectra of mesalamine and hydrocortisone before and after sonication.
  • Fig. S6. Impact of sonication on insulin activity.
  • Table S1. Sample size, regression slope, and R2 values for tissue permeability tests.
  • References (3340)

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