Supplementary Materials

Supplementary Material for:

Antioxidants can increase melanoma metastasis in mice

Kristell Le Gal, Mohamed X. Ibrahim, Clotilde Wiel, Volkan I. Sayin, Murali K. Akula, Christin Karlsson, Martin G. Dalin, Levent M. Akyürek, Per Lindahl, Jonas Nilsson, Martin O. Bergo*

*Corresponding author. E-mail: martin.bergo{at}

Published 7 October 2015, Sci. Transl. Med. 7, 308re8 (2015)
DOI: 10.1126/scitranslmed.aad3740

This PDF file includes:

  • Fig. S1. NAC does not affect expression of melanoma markers and proliferation in primary tumors.
  • Fig. S2. NAC does not affect the size of lymph node metastases and the percentage of proliferating cells.
  • Fig. S3. NAC and Trolox do not affect proliferation of human malignant melanoma cells.
  • Fig. S4. NAC and Trolox do not reduce basal amounts of ROS in melanoma cells.
  • Fig. S5. NAC and Trolox do not affect RAC1 activation, MITF expression, or the expression of MITF target genes.
  • Fig. S6. Antioxidants do not affect DNA damage response, JNK signaling, and epithelial-mesenchymal transition.
  • Table S2. Individual P values for all figures.
  • Table S3. Individual values for GSH, GSSG, and GSH/GSSG ratios in in vivo and in vitro assays.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1. Original data (provided as an Excel file).

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