Supplementary Materials

Supplementary Material for:

TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL

Ilan R. Kirsch, Rei Watanabe, John T. O'Malley, David W. Williamson, Laura-Louise Scott, Christopher P. Elco, Jessica E. Teague, Ahmed Gehad, Elizabeth L. Lowry, Nicole R. LeBoeuf, James G. Krueger, Harlan S. Robins, Thomas S. Kupper,* Rachael A. Clark*

*Corresponding author. E-mail: rclark1{at}partners.org (R.A.C.); tkupper{at}partners.org (T.S.K.)

Published 7 October 2015, Sci. Transl. Med. 7, 308ra158 (2015)
DOI: 10.1126/scitranslmed.aaa9122

This PDF file includes:

  • Fig. S1. HTS studies of blood in patients with circulating expanded benign T cell clones and in the skin lesions of patients with PLEVA.
  • Fig. S2. Comparison of TCRγ PCR studies carried out on DNA from fixed versus frozen skin biopsies.
  • Fig. S3. TCRγ chain PCR results for the third biopsy from patient 551.
  • Fig. S4. A schematic of the approach used by Adaptive Biotechnologies to minimize and control for PCR and sequencing bias.
  • Primary data tables

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