Supplementary Materials

Supplementary Material for:

DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates

Jieun Shin, Tomoki Maekawa, Toshiharu Abe, Evlambia Hajishengallis, Kavita Hosur, Kalyani Pyaram, Ioannis Mitroulis, Triantafyllos Chavakis, George Hajishengallis*

*Corresponding author. E-mail: geoh{at}upenn.edu

Published 30 September 2015, Sci. Transl. Med. 7, 307ra155 (2015)
DOI: 10.1126/scitranslmed.aac5380

This PDF file includes:

  • Methods
  • Fig. S1. Linear structure and functions of the DEL-1 protein.
  • Fig. S2. Inhibition of DEL-1 expression by siRNA treatment.
  • Fig. S3. β2 integrin expression is inhibited by siRNA treatment.
  • Fig. S4. DEL-1 up-regulates BCL6 in human osteoclast precursors undergoing RANKL-induced differentiation.
  • Fig. S5. DEL-1 deficiency enhances osteoclastogenesis.
  • Fig. S6. Features of DEL-1 involved in regulation of osteoclastogenesis and resorption pit formation.
  • Fig. S7. The RGD motif of DEL-1 is involved in its ability to inhibit the resorptive activity of mature osteoclasts.

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