Supplementary Materials

Supplementary Material for:

Human IFNAR2 deficiency: Lessons for antiviral immunity

Christopher J. A. Duncan,* Siti M. B. Mohamad, Dan F. Young, Andrew J. Skelton, T. Ronan Leahy, Diane C. Munday, Karina M. Butler, Sofia Morfopoulou, Julianne R. Brown, Mike Hubank, Jeff Connell, Patrick J. Gavin, Cathy McMahon, Eugene Dempsey, Niamh E. Lynch, Thomas S. Jacques, Manoj Valappil, Andrew J. Cant, Judith Breuer, Karin R. Engelhardt, Richard E. Randall, Sophie Hambleton*

*Corresponding author. E-mail: christopher.duncan{at} (C.J.A.D.); sophie.hambleton{at} (S.H.)

Published 30 September 2015, Sci. Transl. Med. 7, 307ra154 (2015)
DOI: 10.1126/scitranslmed.aac4227

This PDF file includes:

  • Case Summary S1
  • Fig. S1. Antiviral activity of IFN-γ.
  • Fig. S2. IFN-β signaling.
  • Fig. S3. Failure of ISG induction in patient II.2.
  • Fig. S4. IFNAR2 expression in U5A cells.
  • Table S1. Detection of vaccine strain viruses and HHV6 by PCR or viral culture in patient II.1.
  • Table S2. Antibody responses to MMR in patient II.1.
  • Table S3. Immunological and hematological parameters from patient II.1.

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Source data (immunoblots).
  • Data set S1 (Microsoft Excel format). IFN-α microarray.
  • Data set S2 (Microsoft Excel format). IFN-β microarray.
  • Data set S3 (Microsoft Excel format). IFN-γ microarray.

[Download Source Data]

[Download Data Sets S1 to S3]