Supplementary Materials

Supplementary Material for:

A light-reflecting balloon catheter for atraumatic tissue defect repair

Ellen T. Roche, Assunta Fabozzo, Yuhan Lee, Panagiotis Polygerinos, Ingeborg Friehs, Lucia Schuster, William Whyte, Alejandra Maria Casar Berazaluce, Alejandra Bueno, Nora Lang, Maria J. N. Pereira, Eric Feins, Steven Wasserman, Eoin D. O'Cearbhaill, Nikolay V. Vasilyev, David J. Mooney, Jeffrey M. Karp, Pedro J. del Nido,* Conor J. Walsh*

*Corresponding author. E-mail: walsh{at}seas.harvard.edu (C.J.W.); pedro.delnido{at}cardio.chboston.org (P.J.d.N.)

Published 23 September 2015, Sci. Transl. Med. 7, 306ra149 (2015)
DOI: 10.1126/scitranslmed.aaa2406

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Handle component design.
  • Fig. S2. Decoupling mechanism for handle components.
  • Fig. S3. Engineering drawing of the raster rod.
  • Fig. S4. Engineering drawing of the slider sleeve.
  • Fig. S5. Engineering drawing of the handle body.
  • Fig. S6. Energy-dispersive electron spectrometry.
  • Fig. S7. Adhesion testing of the aluminum deposition process on parylene-coated urethane samples.
  • Fig. S8. The inflated balloon approximates an axicon for light simulations.
  • Fig. S9. Light ray analysis for flat- and conical-tipped fibers.
  • Fig. S10. A modified catheter for direct application of light.
  • Fig. S11. Demonstration of transvascular access in the porcine heart.
  • Fig. S12. The patch adheres to the endocardial tissue.
  • Table S1. Reflectivity with various coatings with or without plasma pretreatment.
  • Table S2. Reflectivity with various outer coatings.
  • Table S3. Efficiency for flat and conical tip fiber.
  • Table S4. Pull-off forces in vivo for rat tissues on subcutaneous abdomen.
  • Table S5. Pull-off forces for ex vivo porcine tissues (endocardium, abdominal wall, and stomach).
  • Table S6. Pull-off forces for endocardium and epicardium.
  • Table S7. Burst pressures for case 1 and case 2 for various patch/defect ratios.
  • Table S8. Pull-off forces for different preloads.
  • Legends for movies S1 to S6
  • Reference (38)

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mp4 format). Overview of device functioning.
  • Movie S2 (.mp4 format). Light analysis as conical tip is moved into the balloon.
  • Movie S3 (.mp4 format). Doppler flow before and after VSD closure.
  • Movie S4 (.mp4 format). Patch deployment in vitro and in vivo.
  • Movie S5 (.mp4 format). Patch stabilization in vitro and in vivo.
  • Movie S6 (.mp4 format). Adhered patch in vivo in beating heart.