Supplementary Materials

Supplementary Material for:

Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer

Peter van Luijk,* Sarah Pringle, Joseph O. Deasy, Vitali V. Moiseenko, Hette Faber, Allan Hovan, Mirjam Baanstra, Hans P. van der Laan, Roel G. J. Kierkels, Arjen van der Schaaf, Max J. Witjes, Jacobus M. Schippers, Sytze Brandenburg, Johannes A. Langendijk, Jonn Wu, Robert P. Coppes*

*Corresponding author. E-mail: p.van.luijk{at}umcg.nl (P.v.L.); r.p.coppes{at}umcg.nl (R.P.C.)

Published 16 September 2015, Sci. Transl. Med. 7, 305ra147 (2015)
DOI: 10.1126/scitranslmed.aac4441

This PDF file includes:

  • Materials and Methods
  • Table S1. Planning objectives.
  • Table S2. Tabulated data for Fig. 1H.
  • Fig. S1. Definition of a 3D subvolume by intersection of six truncated subvolumes in orthogonal directions.
  • Fig. S2. Localization of c-Kit+ cells in mouse parotid gland.
  • Fig. S3. Critical regions in patient 1.
  • Fig. S4. Critical regions in patient 2.
  • Fig. S5. Critical regions in patient 3.
  • Fig. S6. Critical regions in patient 4.
  • Fig. S7. Critical regions in patient 5.
  • Fig. S8. Critical regions in patient 6.
  • Fig. S9. Critical regions in patient 7.
  • Fig. S10. Critical regions in patient 8.
  • Fig. S11. Critical regions in patient 9.
  • Fig. S12. Critical regions in patient 10.
  • Fig. S13. Sample locations.
  • Fig. S14. Regenerative capacity of samples.
  • Fig. S15. Fifty percent caudal irradiation.
  • Fig. S16. Fifty percent cranial irradiation.
  • Fig. S17. Fifty percent split field irradiation.
  • Fig. S18. Thirty-three percent caudal irradiation.
  • Fig. S19. Thirty-three percent central irradiation.
  • Fig. S20. Thirty-three percent cranial irradiation.
  • Fig. S21. Twenty-five percent caudal irradiation.
  • Fig. S22. Cranial half of caudal 50%.
  • Fig. S23. Caudal half of cranial 50%.
  • Fig. S24. Twenty-five percent cranial irradiation.

[Download PDF]