Supplementary Materials

Supplementary Material for:

The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma

Monica Venere, Craig Horbinski, James F. Crish, Xun Jin, Amit Vasanji, Jennifer Major, Amy C. Burrows, Cathleen Chang, John Prokop, Quilian Wu, Peter A. Sims, Peter Canoll, Matthew K. Summers, Steven S. Rosenfeld,* Jeremy N. Rich*

*Corresponding author. E-mail: rosenfs{at}ccf.org (S.S.R.); richj{at}ccf.org (J.N.R.)

Published 9 September 2015, Sci. Transl. Med. 7, 304ra143 (2015)
DOI: 10.1126/scitranslmed.aac6762

This PDF file includes:

  • Materials and Methods
  • Fig. S1. iPAGE gene ontology analysis of the Spearman correlation for KIF11 in the NE and CE regions.
  • Fig. S2. Subtype analysis for patient-derived xenograft specimens.
  • Fig. S3. Synchronization of TICs and non-TICs.
  • Fig. S4. Stem cell frequency after KIF11 inhibition.
  • Fig. S5. Representative cell synchronization histograms.
  • Fig. S6. Weights of mice during the orthotopic preclinical study.
  • Table S1. Patient data correlating with the Kaplan-Meier survival curves.
  • Legends for movies S1 and S2
  • References (5153)

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). Representative movie from an untreated organotypic slice culture from a rodent glioma model.
  • Movie S2 (.mov format). Representative movie from an ispinesib-treated organotypic slice culture from a rodent glioma model.

[Download Movie S1]

[Download Movie S2]