Supplementary Materials

Supplementary Material for:

An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease

Sufeng Zhang, Joerg Ermann, Marc D. Succi, Allen Zhou, Matthew J. Hamilton, Bonnie Cao, Joshua R. Korzenik, Jonathan N. Glickman, Praveen K. Vemula, Laurie H. Glimcher, Giovanni Traverso,* Robert Langer,* Jeffrey M. Karp*

*Corresponding author. E-mail: rlanger{at}mit.edu (R.L.); jmkarp{at}partners.org (J.M.K.); ctraverso{at}partners.org (G.T.)

Published 12 August 2015, Sci. Transl. Med. 7, 300ra128 (2015)
DOI: 10.1126/scitranslmed.aaa5657

This PDF file includes:

  • Methods
  • Fig. S1. Additional in vitro characterization of IT-hydrogel.
  • Fig. S2. IT-hydrogel lacks in vitro cytotoxicity against human colon epithelial cells.
  • Fig. S3. IT-hydrogel preferentially adheres to positively charged substrates.
  • Fig. S4. Fluorescent imaging demonstrates adhesion of IT-hydrogel to the inflamed mucosa.
  • Fig. S5. Inflamed colon mucosa retains (DiD + Dex)–loaded IT-hydrogel, but not free dye.
  • Fig. S6. The effect of free Dex or Dex-loaded IT-hydrogel enemas on barrier function in vivo.
  • Table S1. Clinical data of all UC patients (n = 11) recruited for this study.
  • References (3541)

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