Supplementary Materials

Supplementary Material for:

Efficacy of a virus-vectored vaccine against human and bovine respiratory syncytial virus infections

Geraldine Taylor,* Michelle Thom, Stefania Capone, Angiolo Pierantoni, Efrain Guzman, Rebecca Herbert, Elisa Scarselli, Federico Napolitano, Alessandro Giuliani, Antonella Folgori, Stefano Colloca, Riccardo Cortese, Alfredo Nicosia, Alessandra Vitelli

*Corresponding author. E-mail: geraldine.taylor{at}pirbright.ac.uk

Published 12 August 2015, Sci. Transl. Med. 7, 300ra127 (2015)
DOI: 10.1126/scitranslmed.aac5757

This PDF file includes:

  • Fig. S1. BRSV replication in the nasopharynx.
  • Fig. S2. Analysis of cells in BAL 6 days after BRSV challenge.
  • Fig. S3. Kinetics of BRSV IgG and IgA antibodies in serum and nasal secretions.
  • Fig. S4. Vaccination induces BRSV-specific antibody-secreting B cells.
  • Fig. S5. Comparison of serum nAb titers against HRSV and BRSV.
  • Fig. S6. Breadth of T cell response induced by vaccination.
  • Fig. S7. Principal components analysis.
  • Table S6. Clinical score.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Vaccine efficacy in cotton rats.
  • Table S2 (Microsoft Excel format). Vaccine efficacy in calves.
  • Table S3 (Microsoft Excel format). Effect of vaccination on clinical scores.
  • Table S4 (Microsoft Excel format). Effect of vaccination on histopathology scores.
  • Table S5 (Microsoft Excel format). Vaccine-induced immune responses in calves.