Supplementary Materials

Supplementary Material for:

Exposure to SIV in utero results in reduced viral loads and altered responsiveness to postnatal challenge

Chris A. R. Baker, Louise Swainson, Din L. Lin, Samson Wong, Dennis J. Hartigan-O'Connor, Jeffrey D. Lifson, Alice F. Tarantal, Joseph M. McCune*

*Corresponding author. E-mail: mike.mccune{at}ucsf.edu

Published 12 August 2015, Sci. Transl. Med. 7, 300ra125 (2015)
DOI: 10.1126/scitranslmed.aac5547

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Animals exposed to SIVmac1A11 in utero show no difference in the frequency of Tregs after infection.
  • Fig. S2. CD8+ T cell subsets associated with viral load are not different between groups.
  • Fig. S3. Clinical measurements associated with viral load are not different between groups.
  • Fig. S4. Animals exposed to SIVmac1A11 in utero have a lower frequency of IL-2–producing CD4+ T cells after infection.
  • Fig. S5. Animals exposed to SIVmac1A11 in utero have reduced humoral responses after infection.
  • Fig. S6. TH17 cells are directly correlated with CD4+ but not CD8+ T cell proliferation at multiple time points after infection.
  • Fig. S7. Splenocytes from animals exposed to SIVmac1A11 in utero have lower expression of exhaustion markers on CD8+ T cells.
  • Table S1. Residual SIVmac1A11 nucleic acid was found in lymph nodes postnatally.
  • Reference (66)

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