Supplementary Materials

Supplementary Material for:

Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice

Hong Cai, Edwina Scott, Abeer Kholghi, Catherine Andreadi, Alessandro Rufini, Ankur Karmokar, Robert G. Britton, Emma Horner-Glister, Peter Greaves, Dhafer Jawad, Mark James, Lynne Howells, Ted Ognibene, Michael Malfatti, Christopher Goldring, Neil Kitteringham, Joanne Walsh, Maria Viskaduraki, Kevin West, Andrew Miller, David Hemingway, William P. Steward, Andreas J. Gescher, Karen Brown*

*Corresponding author. E-mail: kb20{at}le.ac.uk

Published 29 July 2015, Sci. Transl. Med. 7, 298ra117 (2015)
DOI: 10.1126/scitranslmed.aaa7619

This PDF file includes:

  • Experimental procedures
  • Fig. S1. Effect of resveratrol on cell proliferation and apoptosis in tissues of ApcMin mice.
  • Fig. S2. Effect of resveratrol and HFD on the body weight of female ApcMin mice.
  • Fig. S3. Estimated weekly diet consumption by male and female ApcMin mice.
  • Fig. S4. Effect of resveratrol on the expression of AMPK in the intestinal mucosa of ApcMin mice.
  • Fig. S5. Effect of resveratrol on metabolic parameters in plasma and intestinal mucosa of fasted male ApcMin mice.
  • Fig. S6. Effects of resveratrol in Apc10.1 mouse adenoma cells.
  • Fig. S7. Random expression and phosphorylation of AMPK in colorectal surgical tissue obtained from patients participating in the [14C]-resveratrol trial.
  • Table S1. Plasma pharmacokinetic parameters for total [14C]-resveratrol equivalents in healthy volunteers that ingested a single dose of either 5 mg or 1 g [14C]-resveratrol.
  • Table S2. Tissue concentrations of [14C]-resveratrol species in patients who received resveratrol daily.

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