Supplementary Materials

Supplementary Material for:

Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury

J. Harry Sweigard, Hidetaka Matsumoto, Kaylee E. Smith, Leo A. Kim, Eleftherios I. Paschalis, Yoko Okonuki, Alexandra Castillejos, Keiko Kataoka, Eiichi Hasegawa, Ryoji Yanai, Deeba Husain, John D. Lambris, Demetrios Vavvas, Joan W. Miller, Kip M. Connor*

*Corresponding author. E-mail: kip_connor{at}meei.harvard.edu

Published 22 July 2015, Sci. Transl. Med. 7, 297ra116 (2015)
DOI: 10.1126/scitranslmed.aab1482

This PDF file includes:

  • Materials and Methods
  • Table S1. Human patient data for ELISA samples.
  • Fig. S1. Human samples of RD.
  • Fig. S2. Mouse model of RD.
  • Fig. S3. Complement expression in the mouse RD model.
  • Fig. S4. Cd55 and Cd59 are down-regulated in the detached retina.
  • Fig. S5. Outer nuclear layer expression of complement regulator Cd55.
  • Fig. S6. Expression of several key complement proteins after RD.
  • Fig. S7. The role of the lectin and classical complement pathways in outer nuclear layer cell death after RD.
  • Fig. S8. Cd55 and Cd59 are down-regulated in a photoreceptor cell line during hypoxia, and increasing serum concentrations cause MAC formation.
  • Fig. S9. Hypoxia makes photoreceptors more susceptible to complementmediated cell death.
  • References (59, 60)

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