Supplementary Materials

Supplementary Material for:

Tmc gene therapy restores auditory function in deaf mice

Charles Askew, Cylia Rochat, Bifeng Pan, Yukako Asai, Hena Ahmed, Erin Child, Bernard L. Schneider, Patrick Aebischer, Jeffrey R. Holt*

*Corresponding author. E-mail: jeffrey.holt{at}

Published 8 July 2015, Sci. Transl. Med. 7, 295ra108 (2015)
DOI: 10.1126/scitranslmed.aab1996

This PDF file includes:

  • Materials and Methods
  • Fig. S1. In vivo injection of AAV2/1-Cmv-eGFP through the RWM.
  • Fig. S2. In vivo injection also targets vestibular hair cells.
  • Fig. S3. Exogenous Tmc1/2 restores sensory transduction in Tmc-deficient hair cells in vitro.
  • Fig. S4. Auditory function in wild-type mice injected with AAV vectors.
  • Fig. S5. Confocal images of Tmc1Δ/Δ cochleas injected with AAV2/1-Cba-Tmc vectors.
  • Fig. S6. Confocal images of Tmc1-Bth cochleas injected with AAV2/1-Cba-Tmc2.
  • References (26, 27)

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